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Many drugs is reduced by first pass metabolism, but not cannabis! ItĪlso crosses the blood-brain barrier more easily. Metabolite is more potent, and stays in the system for longer, than THC. Metabolizing into 11 hydroxy delta-9 THC (11-OH-THC). Lack of psychoactivity resulted from THC missing the liver and therefore not Sensi Seeds The rectal veins – superior, middle and inferiorĪssuming that some of the cannabinoid content makes it through the mucus, it then circulates either via the inferior and middle rectal veins into the inferior vena cava, bypassing the liver or via the superior rectal vein to the liver where it is ‘first pass’ metabolized. Since virtually every cannabis suppository I found mentioned online was in a fatty base (as was mine), this should have impaired their efficacy. Therefore active substances that are themselves lipophilic (such as cannabinoids) should not be combined with a fatty or oily carrier if they are intended for rectal use, as this will reduce their overall absorption. It cannot be absorbed directly by the membrane without traversing the aqueous mucus layer. According to “Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products”, the rectum does not absorb fats efficiently.Īny active substance in a suppository must first dissolve into the aqueous mucus that lines the rectum, and then pass into the bloodstream. Analysis of their plasma revealed negligible THC and CBD levels. What is the science behind using cannabis rectally?Īccording to Allan Frankel, MD, who has researched and written about rectal absorption of cannabis, nothing was felt by his test patients when they tried cannabis oil in cocoa butter. Which said maybe it shouldn’t work at all. I found anecdotal reports: “ For me, music starts playing in my head about 1 minute after “dosing”,” “Within minutes I could feel a warm, pleasant sensation washing over my entire pelvic region”. I found practical tips, including ‘lie on your side and bend one leg to make insertion easier’ and ‘don’t pass wind for at least 15 minutes afterwards’. Having procured cannabis suppositories, our preparations were twofold: the classic ‘set and setting’. I had them tested and the results showed 16% THC and 1% CBD, which would definitely give a psychoactive effect if taken in any way that I was familiar with. They were made from butane-extracted whole plant concentrate in a base of coconut oil, giving them a pleasant, almost chocolatey smell, rather like spacecakes. Luckily I was able to obtain some (from a source who wishes to remain anonymous). Step one: Get some suppositories for recreational rectal cannabisĬannabis suppositories are not a product that you can buy in a coffeeshop, nor a pharmacy, even in Amsterdam. However, it’s unlikely to be the sort of thing you can take 20 minutes over in a roomful of friends whilst drinking tea.Īre closer than others, and I was able to enlist a lab partner for my firstįoray into this brave new world. I imagine there’s an element of ritual in rectal cannabis use if one does it frequently enough. When I was a joint smoker I enjoyed the ritual of making the perfect, tasty, smooth-burning cone.
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I am familiar with the concept, but I’ve never been moved to try it. I’d never put cannabis, nor indeed any drug, in my nether regions before.
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Rectal cannabis the last taboo of recreational use? Does it even work? Inserting suppositories, however, has not been broached (at least with me). The subject of savouring a potent high by International hemp fairs to coffeeshops and any given Vocal proponents ofĮvery other kind of cannabis ingestion can be found everywhere, from internet forums and Of cannabis is not a subject I’ve ever heard discussed. For science, for Sensi Seeds, for journalistic integrity, and for pure fun, I tried a cannabis suppository and wrote about the results. Sometimes, the best way to research something is to do it yourself. The scientific and anecdotal reports on rectal cannabis use are surprisingly conflicting.